Zuyue Sun
Shanghai Institute for Biomedical and Pharmaceutical Technologies, China
Title: Advances in prostate pharmacology and toxicology and cutting-edge developments in drug research
Biography
Biography: Zuyue Sun
Abstract
Prostate pharmacology is a specialized area that explores the complex interrelationship between pharmaceuticals and the prostate gland. This discipline includes drug mechanisms, pharmacokinetics, and urofluid dynamics. These components collectively illuminate drug interactions, principles, drug behavior within the body (absorption, distribution, biotransformation, excretion), and how drug effects evolve over time. Furthermore, they encompass processes such as urine flow, urinary flow rate, and bladder pressure.
Conversely, prostate toxicology investigates the effect of external factors, consisting of chemicals, physical elements and biological agents, on the prostate gland. This scientific field examines the severity and frequency of damage, as well as the generation of toxic reactions and the mechanisms that cause toxicity. In addition, it entails both qualitative and quantitative evaluations of the prostate's response to toxic agents.
Testosterone is enzymatically converted into dihydrotestosterone by the action of 5α-reductase. Dihydrotestosterone, exerts a direct stimulatory effect on the proliferation of prostate epithelial cells. This proliferative response results in the enlargement of the prostate gland, which subsequently leads to symptoms such as increased urinary frequency, urgency and retention.